Impregnation of bone chips with alendronate and cefazolin, combined with demineralized bone matrix: a bone chamber study in goats

Impregnation of bone chips with alendronate and cefazolin, combined with demineralized bone matrix: a bone chamber study in goats

BACKGROUND Bone grafts from bone banks might be mixed with bisphosphonates to inhibit the osteoclastic response. This inhibition prevents the osteoclasts to resorb the allograft bone before new bone has been formed by the osteoblasts, which might prevent instability. Since bisphosphonates may not only inhibit osteoclasts, but also osteoblasts and thus bone formation, we studied different bispho...

A bone chamber study in goats

The efficacy of demineralized bone matrix and cancellous bone chips for maxillary sinus augmentation.

Demineralized bone matrix and cancellous bone chips in a reverse-phase medium carrier (DynaBlast, Keystone Dental) were used to augment the maxillary sinuses in 8 patients requiring 10 sinus augmentations. Clinical reentry after 6 to 7 months (mean, 6.2 months) and computed tomographic scan evaluation at 5 months demonstrated new bone formation as well as sufficient radiopaque volume to place i...

Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats

BACKGROUND Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new bone has formed or consolidated enough for loadbearing. Bone resorption can be reduced by bisphosphonates. If resorption of the necrotic bone coul...

Augmentation of Spinal Fusion with a Demineralized Bone/hyaluronan Matrix

INTRODUCTION Autogenous iliac crest bone graft continues to be the material of choice for posterolateral lumbar intertransverse process spine fusion. However, continued interest lies in developing bone graft alternatives that can be used as either graft extenders, graft enhancers, or graft substitutes. It was the purpose of this study to evaluate the efficacy of a demineralized bone matrix/ hya...